Wealthy businessman Isaacman has been formally approved as the next chief of the National Aeronautics and Space Administration, concluding an unusual selection saga where the President put his name forward, pulled the nomination, and then submitted his name once more.
The 42-year-old, an amateur jet pilot who became the first non-professional astronaut to perform a extravehicular activity, is also the first agency head in a generation to come straight from the private sector.
For many, the ultimate measure of his time in office will be decided by one crucial test: if NASA can return humans to the lunar surface in advance of China.
The administration has stated explicitly a desire for the US to establish a lasting moon outpost, both to facilitate resource extraction and to serve as a staging point for missions to the Red Planet.
On This week, the U.S. Senate cleared his appointment with a 67-30 vote.
The President first withdrew the nomination in the spring, citing a "comprehensive examination of prior associations".
At the point, the president was openly clashing with the SpaceX CEO, one of his largest political donors, with whom the nominee has a working relationship.
Isaacman has stated he is now aligned with the administration's goal to extract lunar resources, creating a divergence from Musk, who has stated that focus on the moon is a distraction from the primary objective of reaching Mars.
In the current cosmic competition, nations are competing to utilize the moon's resources.
“Now is not the time for inaction but a time for action because if we lose ground, if we err, we may not recover, and the implications could alter the global dynamics here on Earth,” he told lawmakers recently.
The private sector veteran sees bringing in more private sector competition as essential for achieving those goals, according to a circulated paper outlining his strategy for the agency.
In his testimony, he supported the plan, which he drafted when he was originally put forward, but said it was a developing document.
His support for multiple providers could also cause friction with SpaceX. Last week, Isaacman praised the issuance of a major contract to Jeff Bezos's company, which is one of the main challengers of Musk's SpaceX.
In the document, he suggested NASA should increasingly partner with research institutes, casting the agency as a "force multiplier for science".
He highlighted the scheduled deployment of the Roman Space Telescope as a flagship example.
"Should we be approaching something groundbreaking - like launching Roman - I will leave no stone unturned to make it happen, even providing personal financing if that's what it requires to achieve the discoveries," he remarked.
According to estimates, Isaacman's net worth is estimated at around $1.2 billion, primarily derived from his financial services firm and the sale of his firm that provided flight training and operated a private fleet of military aircraft.
The position of agency chief will be his initial foray in government service, a contrast to the last two people who served as NASA chief.
He will replace Sean Duffy, who has acted as acting administrator since the summer.
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